Katerina Dvorakova

Research Assistant Professor
Cell Biology and Anatomy

Ph.D., University of Arizona 2000
M.S., University of Arizona 1998

Address: 1501 N Campbell
LSN #625
Cell Biology and Anatomy
PO Box 245044
Tucson, AZ 85724
Phone: (520) 626-3934
E-Mail: kdvorak@email.arizona.edu

Research Interests

My major research interest is focused on the role of bile acids and gastric acids in the development of Barrett's esophagus and esophageal adenocarcinoma. We study signaling pathways induced by bile acids and gastric acids in esophageal cell lines as well as in human biopsies with major focus on anti-apoptotic signaling pathways, such as JAK-STAT and NF-kB pathways.

Recent Publications

Bernstein H, Payne CM, Kunke K, Crowley-Weber CL, Waltmire CN, Dvorakova K, Holubec H, Bernstein C, Vaillancourt RR, Raynes DA, Guerriero V, Garewal H. 2004 May. A proteomic study of resistance to deoxycholate-induced apoptosis. Carcinogenesis 25:681-92.

Dvorakova K, Payne CM, Ramsey L, Holubec H, Sampliner R, Dominguez J, Dvorak B, Bernstein H, Bernstein C, Prasad A, Fass R, Cui H, Garewal H. 2004 Mar. Increased expression and secretion of interleukin-6 in patients with Barrett's esophagus. Clin Cancer Res 10:2020-8.

Payne CM, Waltmire CN, Crowley C, Crowley-Weber CL, Dvorakova K, Bernstein H, Bernstein C, Holubec H, Garewal H. 2003 Nov. Caspase-6 mediated cleavage of guanylate cyclase alpha 1 during deoxycholate-induced apoptosis: protective role of the nitric oxide signaling module. Cell Biol Toxicol 19:373-92.

Crowley-Weber CL, Dvorakova K, Crowley C, Bernstein H, Bernstein C, Garewal H, Payne CM. 2003 Mar. Nicotine increases oxidative stress, activates NF-kappaB and GRP78, induces apoptosis and sensitizes cells to genotoxic/xenobiotic stresses by a multiple stress inducer, deoxycholate: relevance to colon carcinogenesis. Chem Biol Interact 145:53-66.

Dvorak B, Halpern MD, Holubec H, Dvorakova K, Dominguez JA, Williams CS, Meza YG, Kozakova H, McCuskey RS. 2003 Mar. Maternal milk reduces severity of necrotizing enterocolitis and increases intestinal IL-10 in a neonatal rat model. Pediatr Res 53:426-33.

Halpern MD, Dominguez JA, Dvorakova K, Holubec H, Williams CS, Meza YG, Ruth MC, Dvorak B. 2003 Jan. Ileal cytokine dysregulation in experimental necrotizing enterocolitis is reduced by epidermal growth factor. J Pediatr Gastroenterol Nutr 36:126-33.

Crowley-Weber CL, Payne CM, Gleason-Guzman M, Watts GS, Futscher B, Waltmire CN, Crowley C, Dvorakova K, Bernstein C, Craven M, Garewal H, Bernstein H. 2002 Dec. Development and molecular characterization of HCT-116 cell lines resistant to the tumor promoter and multiple stress-inducer, deoxycholate. Carcinogenesis 23:2063-80.

Dvorakova K, Payne CM, Landowski TH, Tome ME, Halperin DS, Dorr RT. 2002 Nov. Imexon activates an intrinsic apoptosis pathway in RPMI8226 myeloma cells. Anticancer Drugs 13:1031-42.