Claire Payne

Research Professor of Cell Biology and Anatomy
Ph.D., State University of New York, Stony Brook, 1971

cpayne@u.arizona.edu
(520) 626-2870

Research Interests

Mechanisms of apoptosis in the immune system; role of apoptosis in tumorigenesis; mechanisms of cell death induced by pharmacologic/toxicologic agents.

Research Activities

We have developed colonic epithelial cell lines that are stably resistant to the pro-apoptotic effects of bile acids. These independent clones apparently have become resistant throught different signal-transduction pathways. We are currently working on the mechanisms of apoptosis resistance. We anticipate that this work will lead to the development of intermediate biomarkers that will identify patients that at risk for developing colon cancer.

Publications (Query PubMed for this investigator)

Bernstein, Harris, Claire M. Payne, Kathleen Kunke, Cara L. Crowley-Weber, Caroline N. Waltmire, Katerina Dvorakova, Hana Holubec, Carol Bernstein, Richard R. Vaillanvourt, Deborah A. Raynes, Vincent Guerriero and Harinder Garewal. A proteomic study of resistance to deoxycholate-induced apoptosis, plus Online Supplemenatry Material at http://www.carcin.oupjournals.org Carcinogenesis 25:681-692 (2004).

Payne, Claire M., Caroline N. Waltmire, Cheray Crowley, Cara L. Crowley-Weber, Katerina Dvorakova, Harris Bernstein, Hana Holubec, Carol Bernstein and Harinder Garewal. Caspase-6 mediated cleavage of the catalytic subunit of guanylate cyclase (GC?1) during deoxycholate-induced apoptosis and role of the nitric oxide signaling module in apoptosis resistance. Cell Biology and Toxicology 19:373-392 (2003).

Romagnolo, Donato F., Ryan B. Chirnomas, Jennifer Ku, Brandon D. Jeffy, Claire M. Payne, Lois Ramsey, Kathleen Kunke, Harris Bernstein, Carol Bernstein, Hana Holubec, Achyut Bhattacharyya, James Warneke and Harinder Garewal. Deoxycholate, an endogenous tumor promoter and DNA damaging agent, modulates BRCA1 expression in apoptosis-sensitive epithelial cells: loss of BRCA1 expression in colonic adenocarcinomas. Nutrition and Cancer 46:82-92 (2003).

Crowley C, Payne CM, Bernstein H, Bernstein C, Denise Roe: NAD+ precursors, nicotinic acid and nicotinamide protect cells against apoptosis induced by a multiple stress inducer. Cell Death and Differentiation 7:314-326, 2000.

Dvorakova K, Payne CM, Tome M, Briehl M, McClure T and Dorr RT.: Induction of oxidative stress and apoptosis in myeloma cells by imexon. Bioechem. Pharmacol. 60:749-758, 2000.

Washo-Stultz D, Crowley C, Payne CM, Bernstein C, Marek S, Gerner EW and Bernstein H: Increased susceptibility of cells to inducible apoptosis during growth from early to late log phase: An important caveat for in vitro apoptosis research. Toxicology Letters 116:119-207, 2000.

Bernstein C, Bernstein H, Payne CM and Garewal H: Field defects in progression to adenocarcinoma of the colon and esophagus. Electronic J. Biotechnol. 3:1-17, 2000.

Washo-Stultz D, Hoglen N , Bernstein H, Bernstein C and Payne CM: Role of nitric oxide and peroxynitrite in bile salt-induced apoptosis. Nutrition and Cancer 35:180-188, 1999.

Payne CM, Bernstein C, Bernstein H, Gerner EW and Garewal H: Reactive nitrogen species in colon carcinogenesis., Review. Antioxidants & Redox Signaling 1: 449-467, 1999.

Payne, CM, Bernstein C and Bernstein H: Apoptosis overview emphasizing oxidative stress, DNA damage and signal-transduction pathways. Leukemia and Lymphoma 19:43-93, 1995.